581: Desperatelysafe

Explanation
This comic is a reference to the 2008 RPG Maker game OFF. Here, "the batman" (a man with a baseball bat in the original) is edited to be the game's protagonist, The Batter, with three recruitable party members, Add-Ons, following him.

The title, "Desperatelysafe", is a cross between the source comic series' name, "Buttersafe", and the title of the song "Desperately Safe", which plays in Zone 2 of OFF. The color scheme of this comic is also a reference to Zone 2's color scheme.

The crossed-out eyes on the first man in panel 4 may be a reference to the OFF soundtrack's album art, which depicts a pile of dead ghosts with similar crossed-out eyes.

The author's note suggests listening to "that one tense song with the old-fashioned feel" while reading this comment, which seems at first to refer to the game's iconic battle theme "Pepper Steak", but the author then links an irrelevant song fitting that description, "Fin du Temps" by Art of Noise. "Ah, ah" at the end references a dialogue balloon spawned by the Fat Spectre enemy.

The author writes
Pair your reading of this comic with "Take Me Out to the Ballgame". Or that one tense song with the old-fashioned feel. Oh, right, "Fin du Temps". Ah, ah.

Original Buttersafe strip: 2015-04-14.

Transcript
{There are two guys in ski masks.} Ski mask guy #1: Everybody, run!! It's the Batman!! {A baseball player gleefully runs in-frame. He's followed by three white circles.} {He breaks the first guy's kneecap.} {He bludgeons the second guy over the head.}