619: Red Spiders 3

Explanation
This strip references the "Red Spiders" series of xkcd comics. Like those comics, this is a sketch without any particular joke. The spider in the middle is mentioned in the transcript to be "the size of a house", which could make it a similar size to the red spiders attacking a city in "Red Spiders Cometh", though it has 5 legs instead of 6.

The author's note posits that the scenario depicted actually happened to the author, and that they nearly got paint in their eyes. This could imply that the author either provoked a spider that was covered in paint, or had to cover themselves in red paint to look like a red spider.

The author writes
This actually happened to me once. It was pretty awful. I'm glad I kept the paint out of my eyes.

Original xkcd strips: The Red Spiders strips.

Transcript
{Two spiders are looking at a man. One is red, has five legs, and is the size of a house. The other is about a foot taller than the man, has painted itself red, and looks quite annoyed.} Man: {An indecipherable arcane curse word}